Dharmendra Pratap Singh*, P.K. Singh and Rakhi Kumari
The present study deals with harmful effects of aluminum fluoride on liver functions of albino rats viz. SGPT, SGOT, ALP, total protein, albumin and globulin and their amelioration by vitamin C. The selected thirty-five albino rats of almost equal size and weight (120 ± 25gm) and eight weeks’ old were separated, they were of seven groups, five rats each. The one group of albino rats were treated as control group while aluminum fluoride was given to next three groups of albino rats. In the other three groups of albino rats were first treated with aluminum fluoride in the same way and then given vitamin C dose. The results demonstrated that excessive fluoride ingestion significantly decreased liver function which could be due to toxic effect of aluminum fluoride. Fluoride induced liver dysfunction was mediated by increase of oxidative stress affecting internal milieu in rats. Fluoride had significant adverse effects on serum indexes in albino rats. However, with the introduction of vitamin C to treated albino rats reduced fluoride generated dysfunction due to its ameliorative efficacy.
Keywords: Aluminum, Fluoride, Vitamin C, Albino Rat, SGPT, SGOT, ALP, Total Proteins.