D. P. Singh, Kusum Kushwah*, and P. K. Singh
Aluminum fluoride are reported as heavy metals that induce blood disorders effects. This study was performed to determine the hematological toxicity in male albino rats as affected by the oral administration of 200mg/body weight of aluminum fluoride individually for 30 days. In the present investigations we studied the effect of Aluminum fluoride along for 7, 15 and 30 days on hematological parameters viz. total erythrocyte count, total leucocyte count, hemoglobin concentration, packed cell volume in the blood of albino rats, Rattus norvegicus. Result also revealed that hematocrit value were altered significantly (P < 0.001) after ingestion of fluoride water. The increased WBC count can be related to decreased RBC and hemoglobin content. The tested chemical altered the hematological parameters. Compared to the control, the Hb content decreased uniformly in all groups. The reductions in RBC, WBC and PCV values were greatest in F- treated rats, platelets decreased most in 30 days The differential leucocyte counts varied little between treated groups. Aluminum has a direct effect on hematopoiesis. Exposure to Al therefore, decreased Hb, TEC and PCV in rats. Aluminum also inhibits erythropoiesis and iron metabolism which may hinder hemoglobin synthesis and erythroid cell maturation. Our findings on AlF3 suggest that it is similar to Al3+ in causing toxic effects on animal hematology.
Keywords: Heavy metals, Hb, TEC, PVC, WBC, Albino Rat, etc..